A timeline of the most important things to happen to ER

By Abby West
April 02, 2019 at 09:00 AM EDT

1 of 11

September 19, 1994

Ron Galella, Ltd./WireImage

Season 1 begins, and will go on to win eight Emmys, including Juliana Margulies' for best supporting actress.

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2 of 11

September 26, 1996

Sven Arnstein/NBC/NBCU Photo Bank via Getty Images

Jeanie Boulet (Gloria Reuben) learns she has HIV; many other regulars will face their own health crises.

3 of 11

May 14, 1998

Paul Drinkwater/NBCU Photo Bank

ER gets its biggest audience ever — 47.8 million viewers — when it follows the Seinfeld finale.

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4 of 11

February 18, 1999

NBC

George Clooney leaves the show, but will return for a surprise cameo in 2000 for Margulies' ER swan song.

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5 of 11

September 30, 1999

Hopper Stone/NBC

Goran Visnjic joins the cast, eventually becoming the show's new romantic center with Maura Tierney.

6 of 11

November 16, 2000

NBC

Sally Field plays Tierney's mom, and wins an Emmy. Future Emmy bait: Ray Liotta and Don Cheadle.

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7 of 11

May 9, 2002

NBCU Photo Bank

Succumbing to a brain tumor, Dr. Greene (Anthony Edwards) is one of six hospital staffers to die thus far.

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8 of 11

September 25, 2003

Kelsey McNeal/NBCU Photo Bank

Season 10 begins: Parminder Nagra, Scott Grimes, and Linda Cardellini will join the crowded ER.

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9 of 11

May 19, 2005

NBCU Photo Bank

Last original cast member Noah Wyle leaves. Counting return cameos, he appeared in the most episodes: 254.

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10 of 11

November 10, 2005

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John Stamos joins the show, picking up the "hunky doctor" mantle once carried by Clooney and Visnjic.

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11 of 11

April 2, 2009

James Stenson/NBC/NBCU Photo Bank via Getty Images

After past castmembers returned to pay respects, the series ended on episode 332.

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