Doctor Rob Lowe?
In the podcast episode posted Monday, Lowe told host Marc Maron that he had once turned down the part of McDreamy. The now-famous character of Dr. Derek Shepherd eventually went to Patrick Dempsey.
When Maron asked if Lowe had ever turned down an acting project, Lowe responded, “Dude, I turned down Grey’s Anatomy. To play McDreamy.”
“That’s probably cost me $70 million,” Lowe said jokingly, before adding, “Eh, it’s just money.”
“Listen,” the actor continued. “At the end of the day it was like, I watched it when it came out. And when they started calling the handsome doctor ‘McDreamy’, I was like, ‘Yeah, that’s not for me.’”
Dempsey played Derek from the the pilot episode of Grey’s Anatomy in 2005 until 2015, when the character was killed off in a tragic car accident. In the show, Shepherd was married to Dr. Meredith Grey (Ellen Pompeo).
Lowe had no trouble finding success on television, anyway — after turning down the role, he starred on Brothers & Sisters, Parks and Recreation and The Grinder.
On Feb. 28, Grey’s Anatomy made history as the longest-running medical drama on American television (with 332 episodes!) — surpassing ER, the groundbreaking NBC series that premiered in 1994 and signed off after 15 seasons.
Grey’s Anatomy airs Thursdays at 8 p.m. ET on ABC.
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