By Mary Kate Carr
February 08, 2018 at 03:33 PM EST

In a rare moment of talking about his personal life, George Clooney opens up to David Letterman about his wife, Amal Clooney, and their twins on this week’s episode of Netflix’s My Next Guest Needs No Introduction.

In the clip above, Clooney talks about how his purpose in life has changed in recent years — it’s now “not you,” as Letterman phrases it. “I have to say, before I had the twins, I felt that about her. I felt that I met someone who I would absolutely trade my life for. I met someone that her life meant more to me than my life, and I’d never had that experience before.”

Clooney’s revealing interview follows in the footsteps of Letterman’s first guest, 44th President of the United States, Barack Obama. Upcoming guests include Malala Yousafzai, Jay-Z, Tina Fey, and Howard Stern.

The next episode of My Next Guest Needs No Introduction with David Letterman begins streaming on Netflix February 9. Watch the clip from Clooney’s interview above.