Legendary comedian Jerry Lewis, famous for his slapstick humor across all of entertainment, died Sunday of natural causes at age 91.

With a career that spanned many decades and Lewis’ dedication to humanitarian work, especially on behalf of the Muscular Dystrophy Association, he touched many lives throughout Hollywood and beyond.

“Jerry Lewis just died. When I met him, I feel apart, just sobbed. I guess it’s time for that again,” Penn Jillette wrote on Twitter. How did my life get good enough that Jerry Lewis would smile at me? And how sad to lose him. Goodbye to the real, no irony, king of comedy.”

Lewis’ death hit Dane Cook close to home as well, as he described the entertainer as his mentor, while Marlon Wayans called him his childhood “super hero.” “I am because he was,” Jim Carrey noted.

“You invented the whole thing,” Jeffrey Tambor said. “Thank you doesn’t even get close.”