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A camera crew arrives to document the work of Masters and Johnson, but Bill is unsure it's the right way to promote their research.
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Bill and Virginia get back to work while the Masters brothers continue to attempt a reconciliation.
Scars from their childhoods affect Bill and Barbara, who are unwilling to emotionally confront their pasts. Meanwhile, Virginia's sessions with the psychologist suddenly become personal, leading her to a realization she didn't expect, and Libby takes a stand.
Bill and Virginia take a new interest in their patients' sexual dysfunction. Bill becomes secretive while treating a couple for infertility.
The new Masters and Johnson Clinic struggles while Bill has difficulty accepting that Virginia wants to continue seeing other men.
Bill betrays the study when a reporter interviews him for an article, while Virginia tends to Lillian, who has decided to stop cancer treatment.
Tensions rise as Bill and Virginia get to work at the new hospital.
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Bill and Virginia's secret is out, leading to trouble at work.
A boxing match serves as a long, recurring metaphor for Bill and Virginia's relationship and their understanding of strength and power.