EW can exclusively reveal that this year’s Screamfest Horror Film Festival will feature the L.A. premieres of the Johnny Galecki-starring Master Cleanse — about a man who attends a spiritual retreat only to discover that his toxins aren’t the only thing that gets released — and Trash Fire (pictured above), in which Adrian Grenier plays a character who becomes entangled in a horrifying web of lies, deceit and murder. Other local debuts include director Xavier Gens’ The Crucifixion and Fear, Inc., whose plot involves a group of degenerates who can be hired to bring your greatest fears to life. The event is also hosting the U.S. premiere of the inspired-by-real events Finnish film Lake Bodom. As previously announced, this year’s Screamfest ambassador is actress Lydia Hearst, whose credits include Condemned and #Horror.

“We’re so thrilled to announce such a diverse group of films this year,” said Rachel Belofsky, Screamfest Founder and Festival Director, in a statement. “Even in our 16th year, filmmakers continue to push the envelope and amaze us with their incredible imagination, creativity, passion and hard work.”

The Screamfest Horror Film Festival runs Oct. 18-27, at the TCL Chinese Theatre in Hollywood. You can find find the festival’s full first wave of programming announcement at the official Screamfest website.