By Emily Blake
Updated October 20, 2014 at 12:00 PM EDT
Rose Hartman/Getty Images

Fashion designer Oscar de la Renta has died at the age of 82, ABC News is reporting.

The Dominican-born designer died on Monday at his home in Kent, Conn., his wife, Annette de la Renta, has confirmed to multiple outlets. He was diagnosed with cancer in 2006.

Known for his timeless and feminine designs, he became the go-to designer for First Ladies—including Jackie Kennedy, Nancy Reagan, Hillary Clinton, and Laura Bush—and actresses alike. His gowns were a mainstay on Hollywood red carpets, with Audrey Hepburn, Penelope Cruz, Jessica Chastain, Emma Watson, and Blake Lively just a few of the names who have worn his designs. Most recently, he designed Amal Alamuddin‘s wedding dress for her marriage to George Clooney.

Born in Santo Domingo, De la Renta started his fashion career young after moving to Madrid at the age of 18 to study painting. He got his first fashion job at Lanvin-Castillo in Paris in 1961, then moved to New York two years later to work at Elizabeth Arden. In 1965, at the age of 33, he started his own ready-to-wear label.

He is survived by his wife and adopted son, Moises.