By Natalie Abrams
September 15, 2014 at 03:00 PM EDT
Jordin Althaus/Fox

It’s time for Mindy to meet Danny’s mom.

Later this month, Cheers alum Rhea Perlman will appear on The Mindy Project as Annette Castellano—and EW has the exclusive first look at her debut. The Sept. 23 episode finds Mindy determined to win over Danny’s mother. It doesn’t sound like things go well, though, since the episode is called “Annette Castellano Is My Nemesis.”

The Mindy Project returns Sept. 16 at 9:30 p.m. ET on Fox.