By Bronwyn Barnes
January 16, 2014 at 10:55 PM EST
MERT ALAS and MARCUS PIGGOTT for Playboy
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On this day in 1974, Katherine Ann “Kate” Moss was born.

Since being discovered in 1988, the waifish size zero model has ushered in the heroin chic trend of the early ’90s, had a series of high-profile relationships with the likes of Johnny Depp and British rocker Pete Doherty, and partied like it’s her job.

Among Moss’ various highs and lows, some have stood out more than others.

From Calvin Klein to “Cocaine Kate,” click on to see some of Moss’ most memorable moments.

MERT ALAS and MARCUS PIGGOTT for Playboy

In 1992, Moss posed with Mark Wahlberg — then known as Marky Mark — for what would become one of designer Calvin Klein’s most famous ad campaigns. “He and Kate couldn’t stand each other,” Klein told Interview magazine in 2013. “She had gone through some difficult times, and it sometimes came through in the work and in the attitude.” Moss’ explanation for her behavior? “I had a nervous breakdown when I was 17 or 18, when I had to go and work with Marky Mark [Wahlberg] and Herb Ritts,” she told Vanity Fair in 2012. “It didn’t feel like me at all. I felt really bad about straddling this buff guy. I didn’t like it. I couldn’t get out of bed for two weeks. I thought I was going to die.”

Moss made her big screen debut in 1995’s Unzipped, a behind-the-scenes fashion documentary that followed designer Isaac Mizrahi as he prepared to unveil his fall 1994 collection.

Moss credits Johnny Depp with teaching her the golden rule of fame. “He told me ‘Never complain, never explain,'” she told Vanity Fair. “That’s why I don’t use Twitter and things like that. I don’t want people to know what is true all the time and that’s what keeps the mystery.”

The supermodel began dating Libertines frontman –and self-admitted junkie — Pete Doherty in 2005. Every detail of the couple’s tempestuous relationship was covered by the British tabloids, including photographs that appeared to show Moss snorting cocaine. In the wake of the scandal, “Cocaine Kate” lost lucrative endorsement contracts with Chanel, Burberry, and Rimmel London, but less than a year later she had signed new deals with Roberto Cavalli, Stella McCartney, and Virgin Mobile and was raking in more money than ever. In 2007, TIME magazine named her one of the most influential people in the world.

At 39, Moss put on a pair of bunny ears and posed for the cover of the January/February 2014 60th anniversary issue of Playboy, which hit newsstands in December. The supermodel’s 18-page pictorial included full frontal nudity and an interview with Welsh singer Tom Jones, who challenged her to a round of Marry, F—, Kill with Marc Jacobs, Piers Morgan, and Naomi Campbell.

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