With his latest character, Matthew McConaughey continues his streak of playing sexed-up scofflaws (see: Magic Mike, Killer Joe). ”He’s a real bastard,” McConaughey says, ”a drug-taking, ass-running wild man.” The film is based on the real Ron Woodroof, a straight electrician who in 1986 contracted HIV at a time when AIDS was considered a gay disease. Frustrated by a paucity of FDA-approved drugs, Woodroof launched a lucrative business smuggling meds from overseas. ”He was a hustler and a dealer, straight up,” says McConaughey, who lost nearly 50 pounds to play the role. ”It’s a very anarchic story.”

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