By Hillary Busis
Updated March 21, 2013 at 05:05 PM EDT

On March 21, 2006, Twitter founder Jack Dorsey sent the microblogging site’s very first tweet: “just setting up my twttr.” (The “i” and the “e” would come in time.)

Seven years later, it’s tough to imagine a world without hashtags, @-replies, and the Fail Whale — not to mention the major news events in which Twitter has played a vital role, from the Arab Spring to the downfall of Congressman Anthony Weiner. The site charts several of those highlights in this charming anniversary video, which starts with Twitter’s humble beginnings as a sketch on a legal pad and ends with the future, a.k.a. Vine. US Airways Flight 1549, Barack Obama, and even Oprah (“HI TWITTERS”) pop up along the way as well.

Which major moments in tweet-dom would you add to this reel — @BronxZoosCobra? The moment Demi Moore went from @mrskutcher to @justdemi? That time a couple supposedly named their baby Hashtag?

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