By Nuzhat Naoreen
September 14, 2012 at 05:26 PM EDT

Between the presidential elections and very important pop-culture developments like this, first-time Saturday Night Live host Seth MacFarlane has a lot of ground to cover when he takes the reins during the season premiere of the sketch comedy series this weekend. But one topic the Ted and Family Guy creator likely won’t touch is the heart-wrenching headline-blazing breakup between Robert Pattinson and Kristen Stewart.

“Who f**ing cares?” MacFarlane told EW, after we gave him a quick primer on the obsession that is “Robsten,” during rehearsals for SNL. “I still have my house, my cat is still alive. I don’t care what happens.” (Make sure to watch the video below to see his complete hilarious reaction).

MacFarlane will be joined on the show by musical guest Frank Ocean, who he described as “immensely talented.”

“That’s nice to see in a music industry plagued with huge acts that are not so talented,” he said.

Watch the video below to see MacFarlane’s confusion over “Robsten,” and to find out what advice he received before hitting the set.

Now that we know Robsten’s off the table, who or what do you want to see Seth MacFarlane parody on the premiere?

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