The Duplass brothers — Jay and Mark — have enjoyed great critical success in the festival hinterlands, where they’ve perfected their own version of naturalistic mumblecore filmmaking. Their last film, Cyrus, flirted with the mainstream, starring John C. Reilly, Jonah Hill, and Marisa Tomei, but Jeff, Who Lives at Home, which debuted at last fall’s Toronto Film Festival, might be their official breakthrough. Jason Segel plays naive mope Jeff, who is convinced the universe is trying to tell him something, and Ed Helms is his more alpha-dog older brother whose own life is on the precipice.

Take a look at the trailer, with its faint echoes of The Descendants — right down to the presence of Judy Greer.

The film opens March 16.

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