By Jeff Labrecque
Updated December 08, 2011 at 09:46 PM EST

Richard Dreyfuss, Ellen Burstyn, James Woods, Geena Davis, Lauren Ambrose, and Steven Pasquale (Rescue Me) will star in Coma, a four-hour miniseries based on the Robin Cook novel that will air on A&E.

Directed by Mikail Salomon (Band of Brothers) and produced by Tony and Ridley Scott, Coma is a thriller “about a doctor who discovers that something sinister is going on in her hospital after routine procedures send more than a few seemingly healthy patients into comas on the operating table.”

John J. McLaughlin (Black Swan) is writing the script, and the two-night event from Sony Pictures Television is scheduled to premiere Memorial Day 2012.