In HBO’s new fall dramedy, Enlightened, Laura Dern plays Amy Jellicoe, a self-destructive corporate exec who lands herself in a Hawaiian mental-health treatment center after suffering a nervous breakdown. When she emerges from rehab, the world looks a little different and she begins to reconsider her role in it.

“Picture if you will, if Lucy [Ricardo] became Norma Rae,” Dern told EW on the set last year. “You know, America has become so complacent, how could we have fun with the question of who still has a voice in America? It [would] be the reactive, prickly person who probably most of the time won’t say it or do it right, but in fact is bold enough to say ‘This is unacceptable.'”

Click below for an exclusive first look at the show’s in-your-face poster.

Enlightened, written and executive produced by Mike White (The Good Girl), also stars Luke Wilson and Diane Ladd. It premieres Oct. 10 on HBO. (Reporting by Adam B. Vary)