By Dan Snierson
August 19, 2011 at 03:00 PM EDT
Albert L. Ortega/PR Photos

He may be known best these days for playing a meth kingpin on Breaking Bad, but Bryan Cranston is set to moonlight for one night as an action hero on The Simpsons. EW has learned that the three-time Emmy winner will voice Stradivarius Cain, a suave Hollywood superspy whom Homer sees as an illusion after suffering a head injury. Cain has a very important mission: to make Homer into a man that Marge can’t resist.

The episode, titled “The Spy Who Learned Me,” is slated to air in spring 2012. The animated comedy’s 23rd season, which debuts Sept. 25 on Fox, will also feature the guest voices of Jane Lynch, Michael Cera, Andy Garcia, Jeremy Irons, Joan Rivers, and Kiefer Sutherland.

Twitter: @dansnierson

Read more:

10 things we learned about ‘The Simpsons’ at Comic-Con

See a clip from ‘The Simpsons’ Halloween episode featuring Ned Flanders as… Dexter! — EXCLUSIVE VIDEO

Armie Hammer to play the Winklevoss twins again… on ‘The Simpsons’! — EXCLUSIVE