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Who will preside over a must-see evening of Charlie Sheen being skewered on Comedy Central?

None other than Family Guy creator Seth MacFarlane.

Comedy Central has tapped the acerbically funny writer-actor-producer to host the ceremonious roasting of the former Two and a Half Men star. To get an idea of what we’re in for, here is MacFarlane on his acceptance of the gig: “I’m very excited to work with Comedy Central again on the roast,” MacFarlane said. “Charlie is a true icon with a talent that is strong and pure and concentrated into small crystals which can be smoked or eaten.”

Yup, the Sheen jokes are sure to crack you up!

Added Comedy Central programming head Kent Alterman on snagging MacFarlane: “In addition to his sharp wit, Seth is way more suave and sophisticated than we are. We continue to try and soil him.”

In fact, this will mark MacFarlane’s third time presiding over a Comedy Central celebrity roast, the only person to ever undertake the role three times.

The special event premieres on Sept. 19 at 10 p.m., the same night as the return of CBS’ Men.