By Sandra Gonzalez
August 04, 2011 at 10:46 AM EDT

The dust is barely settling from Lisa Edelstein’s exit from House, but is Dr. Crankypants already on the rebound? Not exactly. But when Brothers & Sisters alum Odette Annable crosses paths with House in the season premiere on Oct. 3, there will be “a connection” says executive producer David Shore.

“She’s working in prison and there’s a bit of a connection — not a physical connection. But she doesn’t really know House. He’s just a prisoner. Then things change,” he says. “He changes her, and she changes him.”

With Edelstein’s unexpected departure, Shore said the team is looking to return to “the basics” of the show and “the fundamental questions of right and wrong.” But in doing so, the show added two new faces — both Annable and Knocked Up actress Charlene Yi will be joining the team this season.

Shore says of Annable: “She’s great, she’s smart, she’s funny. We’re excited about it.”

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