By Mandi Bierly
Updated September 27, 2010 at 09:01 PM EDT

George Lopez and his wife, Ann, are ending their 17-year marriage. “The decision is amicable and by mutual agreement,” a rep for the Lopez Tonight host confirms in a statement. “They remain dedicated parents, and committed partners in business and their philanthropic organization, The Lopez Foundation.” The couple made headlines in 2005, when Ann donated one of her kidneys to her ailing husband, who was born with narrow ureters. The Lopez Foundation increases community awareness about kidney disease, organ donation, and the importance of seeking routine medical care for all health issues.

Breaking up is hard to do

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