September 20, 2010 at 10:49 PM EDT

Image Credit: Ray Mickshaw/FoxDon’t count on seeing much of Thirteen on House this season.

According to series creator David Shore, Olivia Wilde—who took a leave of absence this fall to shoot a starring role in the big-budget sci-fi Western Cowboys and Aliens—will be gone for more than just a handful of episodes.

“It’s going to be a while unfortunately,” sighs series creator David Shore. “We love her but it is going to be a while. It’s going to be this season, but well into this season.”

The news comes as Wilde’s movie career is heating up big-time. The actress has four films in the pipeline (Cowboys and Aliens included), and recently signed a deal to join Ryan Reynolds and Jason Bateman in the body-swapping comedy The Change Up.

Shore says Wilde’s Change Up shooting schedule won’t further delay her return to Princeton Plainsboro. “She called us up and said she wanted to do [The Change Up],” he explains. “And it just so happened that what we had worked out storyline-wise allowed her a couple of extra episodes [off]. So that movie just filled in the gap. There were no further adjustments to her schedule as a result of that.”

Bottom line: Enjoy Thirteen’s appearance in tonight’s House premiere, because it’s the last one you’ll be getting for a while.

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