August 04, 2010 at 06:20 PM EDT

A star-studded new PSA promoting this year’s fundraising Stand Up to Cancer telecast (Sept. 10, 8 p.m. ET, on 14 networks) is effective, both in terms of hammering home what the odds are that we will get cancer in our lifetime (1 in 2 men, 1 in 3 women), and making me feel old. There are two young stars that I did not recognize. Thank goodness I’m up on my Spider-Man 4 casting, or it would have been three. Watch the promo below. Visit standup2cancer.org for more information and to donate.

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