By Kate Ward
Updated March 17, 2010 at 07:12 PM EDT

Ready to rock and roll all night (and furiously remove make-up ev-er-y day) with Gene Simmons? You better be, because the season 5 premiere of A&E’s Gene Simmons Family Jewels is just a few days away (March 21 at 9 p.m.). And by the looks of this exclusive clip — which shows Shannon Tweed getting a biopsy and Gene embarking on, and then canceling, a tour — we better gear up for a dramatic season.

What else can we expect from season 5? According to A&E’s press release, Sophie graduates high school, Gene turns 60 years old, and Nick rocks out at Comic-Con to launch his graphic novel, Incarnate. But there’s more to celebrate: This season sees Family Jewels‘ 100th episode. So will you tune into watch what Gene himself calls “the most unconventional conventional family”?