By Keith Staskiewicz
Updated February 26, 2010 at 09:00 PM EST

Christina Applegate and Alyssa Milano have signed on for the Farrelly Brothers’ latest comedy Hall Pass, according to The Hollywood Reporter. The film, about two husbands given a week-long carte blanche by their wives to sleep around, already features a cast that includes Owen Wilson, Jason Sudeikis, Jenna Fischer, and Amanda Bynes. Applegate most recently demonstrated her comedy chops on the now-cancelled sitcom Samantha Who? Also joining the cast are Larry Campbell and Vanessa Angel.