By Adam Markovitz
Updated February 25, 2010 at 10:52 AM EST

Natalie Portman is set to produce and star in the stoner road trip comedy Best Buds, according to Variety. The actress will play a bride-to-be who blows off her wedding for a marijuana-fueled drive to San Diego with two of her best friends. Other upcoming projects for Portman include this fall’s fantasy comedy Your Highness, the upcoming Darren Aronofsky thriller Black Swan, and Kenneth Branagh’s comic book adaptation Thor.