By Michael Ausiello
February 03, 2010 at 12:00 PM EST

Lost heroine Cynthia Watros has found herself one hell of a plum role on House.

Sources confirm to me exclusively that the Emmy-winning actress has been cast as Wilson’s first ex-wife (he’s had three) who comes back into his life as his new girlfriend.

And this isn’t some passing fling. I’m told Watros is on board for multiple episodes, the first of which is slated to air in April. Ironically, that’s right around the time she’s slated to reappear on Lost as Libby.

This marks the first significant romantic entanglement for House’s BFF since the death of Amber nearly two years ago.

Thoughts?! Are you as psyched about this as I am? ‘Cause I’m pretty psyched.

Photo Credit: Leonard: Florian Schneider/Fox; Watros: Gina James