If Friday’s numbers hold, Avatar will have held off the competition at the box office for yet another weekend. The James Cameron spectacle earned an estimated $7.3 million yesterday, putting its total domestic gross at $572 million, ahead of second place Edge of Darkness, the R-rated Mel Gibson-starrer, which brought in an estimated $5.7 million for its first day in theaters. Disney’s romantic comedy When in Rome managed to eke out third place at the weekend derby, despite miserable reviews, earning an estimated $4.4 million for its opening day. The film surpassed third-weekend holdover Book of Eli, which grossed an estimated $2.5 million. Fifth place for the day went to the The Tooth Fairy, which in its second Friday in theaters took in only $2.3 million, a number that doesn’t bode well for the film’s second weekend hold. Check back tomorrow and I’ll have the full numbers.