Three-time Pulitzer Prize and Tony Award winner Edward Albee will open Playwrights Horizons’ 40th anniversary with his new play, Me, Myself & I. The show — which will premiere in August 2010 at the company’s Mainstage Theater in New York — follows identical twin brothers with the same name. “As a writers’ theater, it feels unspeakably lucky and fitting to launch our season with this giddily entertaining and challenging play by our pre-eminent living playwright,” Horizons Artistic Director Tim Sanford said in a press release. Emily Mann has been tapped to direct, while Elizabeth Ashley and Brian Murray are poised to star in the play. Other casting decisions will be announced in the coming months.