By Michael Ausiello
November 09, 2009 at 11:24 PM EST

Mer’s self-injuring Grey’s Anatomy BFF has hopped the crazy train over to Lie to Me.

Melissa George is joining the Fox drama as an Anna Nicole Smith-type who will go toe-to-toe with Tim Roth, sources confirm to me exclusively.

Her character, Clara Martin, is the sassy wife of an older billionaire who has been murdered. After being exonerated in a high-profile murder trial, she assumes control of her husband’s empire. Lightman sees himself in her — naughty, fearless, strategic, and always game for the next adventure. In other words, she’s kinda nuts.

George will recur beginning with this season’s 11th episode.

PHOTO CREDIT: George: Bob Charlotte/PR Photos; Roth: Fox