By Michael Ausiello
October 13, 2009 at 12:00 PM EDT

They don’t literally check into Seattle Grace. ABC would never allow that. Instead, the Nov. 5 episode — appropriately titled “Changing Channels” — finds the brothers Winchester trapped in some very familiar TV settings. In addition to their Grey’s Anatomy cameo (pictured), Sam and Dean cross over into a CSI-type series as well as a traditional sitcom. Word on the street is that the cheeky Grey’s bit features several nods to the actual ABC drama, including one that Supe fans will find particularly amusing. Guesses?