By Wendy Mitchell
Updated August 05, 2009 at 04:15 AM EDT

Katherine Heigl may soon have a new leading man — Josh Duhamel is in talks to star opposite her in Life as We Know It, according to Variety.

Greg Berlanti will direct the Warner Bros. romance. Heigl and her mother Nancy are executive producing the film. The script, written by Ian Deitchman and Kristin Rusk Robinson, is about two unattached adults whose mutual best friends die in an accident and leave the unlikely pair in charge of their orphaned daughter.