April 24, 2009 at 04:51 PM EDT

Denzel Washington is in talks to star in director Tony Scott’s Unstoppable, according to Variety. The Oscar-winning actor would play an engineer who chases after a runaway train carrying toxic chemicals. The drama, which is scheduled to begin production in the fall, marks Washington and Scott’s fifth collaboration, the most recent of which is June’s The Taking of Pelham 1 2 3.

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