Who annoyed Dr. House most?

There’s a long line of recurring characters who’ve nettled, unsettled, or otherwise tried to destroy the choleric doc. Who’s come closest to making House’s blood truly boil?

Stacy Warner
Sela Ward
Seasons 1, 2
The hottie ex-girlfriend drove House nuts as she batted her lashes while begging the understandably frustrated doc to save her sick husband. Temperature: 140 degrees

Michael Tritter
David Morse
Season 3
As a vengeful cop, Morse didn’t take kindly to a rude encounter with House — so he aimed to toss the doc behind bars, while fiercely targeting everyone he knew. Temperature: 210 degrees

Amber Volakis
Anne Dudek
Season 4
House dubbed the job seeker ”Cutthroat Bitch,” but she was a bigger threat to him as Wilson’s squeeze. The trio were forced to hammer out a custody agreement for Wilson’s time. Temperature: 170 degrees

Lucas Douglas
Michael Weston
Season 5
House uses PI Douglas as his surrogate pushy jerk and reluctant fill-in friend, making the pro snoop the only visitor who might actually be welcomed back. Temperature: 100 degrees