Eddie Murphy and Vince Vaughn are some of the funny guys who rule the box office

By Adam Markovitz
April 06, 2007 at 04:00 AM EDT

Ben Stiller
BIGGEST COMEDY OPENING $47.2 million (Madagascar, 2006)
UP NEXT He reteams with the Farrelly brothers, playing a man who falls for another woman on his honeymoon in a film based on 1972’s The Heartbreak Kid (out Oct. 5).

Adam Sandler
BIGGEST COMEDY OPENING $47.6 million (The Longest Yard, 2005)
UP NEXT Joins The King of Queens star Kevin James as firemen who pretend to be gay for the domestic benefits in July 20’s I Now Pronounce You Chuck & Larry.

Eddie Murphy
BIGGEST COMEDY OPENING $108 million (Shrek 2, 2004)
UP NEXT On May 18, he makes an ass of himself yet again as Donkey in Shrek the Third. Then he’ll take off in Starship Dave, a sci-fi farce costarring Gabrielle Union.

Vince Vaughn
BIGGEST COMEDY OPENING $39.2 million (The Break-Up, 2006)
UP NEXT Plays Santa’s less-than-jolly brother in Fred Claus (Nov. 9). And a documentary about his stand-up tour, Wild West Comedy Show, is awaiting release.