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Still a rising star with one studio album to her name, Adele stopped by Ugly Betty for a guest appearance in 2009. The singer, who dropped 19 the year prior, appeared as herself, meeting Betty as a part of one of her projects for work.
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Naomi Campbell graced Ugly Betty with her presence in 2008, appearing as herself in one season 2 episode. She steps in as the ringer for Elle's softball team in a charity game between the magazine and Mode.
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Martha Stewart made an appearance in Ugly Betty's first season, playing herself in a 2006 installment. The lifestyle maven comes to Wilhelmina's rescue as she attempts to prepare a Thanksgiving dinner.
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Christie Brinkley joined Ugly Betty for one season 4 episode in 2009. The model played Penelope Graybridge, Wilhelmina's main competition in the magazine world.
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Victoria Beckham made an appearance as herself in the show's second season. The former Spice Girl found her way into a 2007 episode as Wilhelmina's maid of honor at her wedding.
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Shakira stopped by Ugly Betty's fourth season in 2009. The singer played herself, meeting Betty in the Bahamas.
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Kristin Chenoweth joined Ugly Betty's first season as Diane, a technician in Betty's orthodontist's office.
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The year after he wrapped his run as Alias' Jack Bristow, Victor Garber became Ugly Betty's Professor Barrett for one 2007 episode. The actor appeared in the second season as one of Betty's instructors.
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Betty White made a guest appearance on Ugly Betty in 2007. The famed actress played herself in season 2, coming into contact with Wilhelmina over a mutually desired cab.
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Rachel Dratch took on two roles in Ugly Betty's third season. The funnywoman played twin sisters Penny and Mindy Meadows, the former of whom dies after falling out the window of the office.
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Brooklyn Decker took on the role of Lexie in the fourth season of Ugly Betty. The model appeared as Daniel's attractive new assistant.
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James Van Der Beek
After saying goodbye to Dawson Leery, James Van Der Beek made a 2007 appearance in Ugly Betty as Luke Carnes. He appeared in the second season installment as a designer who works with Daniel.
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Mo’Nique stopped by Ugly Betty for one season 2 episode in 2007. The actress played L'Amanda, a weekend security guard at Mode.
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Patti LuPone made an appearance in Ugly Betty's first season. She played Marc St. James' mother, Mrs. Weiner.
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Kathy Najimy stopped by Ugly Betty's fourth season in 2010. She played Dr. Frankel, Betty's orthodontist.