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10. Sure, Alex Karev can be sort of a jerk, but if everyone you'd ever loved or tried to protect went cuckoo-bananas and abandoned you, maybe you'd have some intimacy issues too. In ''Freedom Part 2,'' Alex finally broke down over Ava and the emotional torture of their tangled relationship. Unfortunately, he did it while making out with Izzie. But still. Sad.
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9. Meredith's relationship with her father was fraught from the beginning, and her inadvertent role in her stepmother's death didn't help things. But we never expected Thatcher to slap her. Dr. Grey wasn't the only one shocked into a few tears.
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8. Burke and Cristina's tumultuous romance had plenty of gasp-worthy moments, but it was the shocking tenderness at the end of ''Deny, Deny, Deny'' that got us misty. Cristina's tear-streaked face when she gazed up at the impeccably put-together Burke is one thing, but when Burke (and his perfect turtleneck) climbed onto the bed to hold her? Oh, the crying.
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7. The whole story arc of George's father's death was of course very sad, but the narrative took a poignant turn in the closing moments of ''Six Days: Part 2.'' Cristina, never George's closest friend, reached out to him, and told him about the ''dead-dads club.'' ''I'm really sorry you had to join the club,'' she said, swallowing hard. Excuse me while I go cry for infinity years.
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6. The second part of the post-Super Bowl episode had plenty of sob-inducing moments: Kyle Chandler's bomb-squad dude getting blown to bits, for example. Or George helping a frightened Bailey deliver her son, for another. But those major adrenaline moments didn't hold a candle to Derek's wistful, romantic, aching monologue reminding Meredith what their last kiss was like: ''It was a Thursday morning. You were wearing that ratty little Dartmouth T-shirt you look so good in. The one with the hole in the back of the neck. You had just washed your hair, and you smelled like some kind of flower. I was running late for surgery, and you said you were going to see me later. Then you leaned to me, and you put your hand to my chest, and you kissed me. Soft. It was quick, kind of like a habit. Like we'd do it every day for the rest of our lives. You went back to reading the newspaper, and I went to work. That was the last time we kissed.''
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5. When McDreamy cries, the whole world cries. Meredith's near-drowning in ''Some Kind of Miracle'' brought on a deluge of handsome, handsome tears. ''She knows how to swim,'' he choked out. ''She's a good swimmer.'' In that moment, Derek acknowledged both the depths of Meredith's depression and his own helplessness in the face of it.
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4. George earned the nickname 007 in the first season, and when he traced the numbers on Meredith's hand so she'd recognize him in his badly mangled state, she was overcome with fear. The whole segment, cutting back and forth between what seemed like George and Izzie's final moments together, put us over the edge.
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3. ''Death and All His Friends'' had plenty of wrenching scenes — the episode itself was basically one giant exploration of shock and sadness. Things went from ''Wow, this is sad and intense'' to ''Well, I may never fully recover from how hard I am crying right now'' when Bailey discovered the elevators weren't working. First she panicked, then she fell apart... and then she cradled the dying Charles and comforted him in his last moments. Unreal.
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2. Patient deaths on Grey's, while often deeply sad, rarely pack the same punch as the deaths of regular characters. Except for Bonnie's in ''Into You Like a Train.'' It's one of the show's best episodes ever — astoundingly melodramatic in the most wonderful possible ways — and Monica Keena lent Bonnie an innocent sweetness that made the character's death all the more crushing. ''Do you believe in heaven?'' Bonnie whispered, shortly before the doctors removed the pole sticking through her abdomen. That's when the waterworks started. But they escalated into full-on sobs when Bonnie flatlined and Meredith — dealing with her own abandonment issues — was suddenly the only doctor left working on her. ''What about her?!'' she wailed. (More tissues, please.) Finally, Derek had to tell Bonnie's boyfriend her dying words: ''If love were enough, she'd still be here with you.'' Am I ever going to stop crying? Nope, never.
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1. We all knew it was coming. Heck, from the second Denny Duquette materialized at Seattle Grace, it was clear the clock was ticking. But man oh man, after the LVAD drama, and the proposal, and everyone in party clothes — oooof. If you'll excuse us, there's a bathroom floor that we need to lie on.