1 of 10
Best Motion Picture, Drama
Will win and should win: Up in the Air
Avatar has the momentum in the overall awards-season race, but with the most Globe nominations this year (six in all), the much more starry Up in the Air should steal it.
THE WINNER: Avatar
2 of 10
Best Motion Picture, Comedy or Musical
Will win: (500) Days of Summer
Should win: It's Complicated
With top comedy/musical nominee Nine fading from prominence every day, Globes voters may look elsewhere for the win. Meryl Streep voters could find themselves split between Julie & Julia and the outrageously funny It's Complicated, paving the way for a (500) Days victory.
THE WINNER: The Hangover
3 of 10
Best Actor, Drama
Will win: George Clooney, Up in the Air
Should win: Colin Firth, A Single Man
In one of the year's closest races, all the love for Up in the Air stands to send Clooney over the top. Clooney and Crazy Heart's Jeff Bridges are both wonderful, but it's Firth who's truly transporting in Tom Ford's sumptuous drama.
THE WINNER: Jeff Bridges, Crazy Heart
4 of 10
Best Actress, Drama
Will and should win: Carey Mulligan, An Education
There's a chance The Blind Side's Sandra Bullock could upset, but the race is really between two poised newcomers: Carey Mulligan and Precious' Gabourey Sidibe. Give the British Mulligan the edge with the HFPA.
THE WINNER: Sandra Bullock, The Blind Side
5 of 10
Best Actor, Comedy/Musical
Will win: Daniel Day-Lewis, Nine
Should win: Matt Damon, The Informant!
With no real frontrunner, it's anyone's trophy. If Nine has a shot at any of its five nominations, it's in this category. But my vote goes to Damon for his riotously funny, yet criminally unseen, turn as the world's worst whistle-blower.
THE WINNER: Robert Downey Jr., Sherlock Holmes
6 of 10
Best Actress, Comedy
Will and should win: Meryl Streep, Julie & Julia
Streep's toughest competition? Herself, for It's Complicated. But she'll easily win for playing a real person so perfectly in Julie & Julia.
THE WINNER: Meryl Streep, Julie & Julia
7 of 10
Best Supporting Actor
Will and should win: Christoph Waltz, Inglourious Basterds
The supporting races are by far the easiest to call this year. And for good reason: Waltz's breakout performance as a multi-lingual SS colonel is one for the ages.
THE WINNER: Christoph Waltz, Inglourious Basterds
8 of 10
Best Supporting Actress
Will and should win: Mo'Nique, Precious
The Up in the Air ladies are lovely, and it's criminal that A Single Man costar Julianne Moore's mantel is empty. But Mo'Nique is simply in a league of her own this year.
THE WINNER: Mo'Nique, Precious
9 of 10
Will win: James Cameron, Avatar
Should win: Kathryn Bigelow, The Hurt Locker
The Hollywood Foreign Press Association adores Avatar. Here's its easiest victory. Though Bigelow is to be commended with creating so much suspense with a much smaller budget.
THE WINNER: James Cameron, Avatar
10 of 10
Best Animated Film
Will and should win: Up
Wes Anderson's Fantastic Mr. Fox would be a worthy winner in another year. But give Up the win based on those opening 10 minutes alone.
THE WINNER: Up
More Golden Globes predictions from EW:
TV: Ken Tucker predicts who will win — and who SHOULD