1 of 7
Bryan Cranston (Walter White)
Walt watches as Jane (Krysten Ritter) dies of a drug overdose (season 2)
"It was a harrowing time to play that guy.... It's so rich and layered. At one moment, I actually pictured my own daughter dying, and that was upsetting. But that's what we do."
2 of 7
Anna Gunn (Skyler White)
Walt discovers that the money in the crawl space is missing (season 4)
"That shot of him laughing maniacally down in the crawl space — that was brilliant. It was his descent into that mental space; it reflected what was going on with him emotionally."
3 of 7
Aaron Paul (Jesse Pinkman)
Jesse has an awkward dinner at the White house (season 5)
"That was so fun, just how uncomfortable it was sitting in between Mr. and Mrs. White and realizing there is tension between the two. Jesse's using the glass of water like his security blanket."
4 of 7
Dean Norris (Hank)
Hank has a showdown with Walt in his garage (season 5)
"We've been building up to it for five seasons: When was Hank going to find out, and what was he going to do? It was so shocking for him to punch Walt and to let it all out right there."
5 of 7
Betsy Brandt (Marie)
Skyler stages a family intervention to urge Walt to seek treatment for his lung cancer (season 1)
"You saw everybody's idiosyncrasies come through in a wonderful way.... I sent Vince [Gilligan, who created the show,] an email and I said, 'I was so pumped after that, I wanted to have T-shirts made: Intervention 2008.'"
6 of 7
Bob Odenkirk (Saul)
After his ricin revelation, Jesse brutally confronts Saul in his office (season 5)
"Aaron Paul is so good in that scene. Standing three feet away from somebody who's tearing up the space-time continuum like that is just an amazing thing to experience."
7 of 7
RJ Mitte (Walt Jr.)
Jesse explains the "cow house" to Walt while they're out in the desert on a cook (season 1)
"It's so much like a dark comedy. I love the simplicity. 'Cow house?' 'Yeah. Where they live, the cows.' I was just like, 'Oh my God, that's hilarious.'"