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Angela Bassett graced The Bernie Mac Show with her Golden Globe-winning presence in 2003. The What's Love Got to Do with It actress played herself, appearing in the third season as a mentor to Bernie as he chases an acting career.
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Matt Damon stopped by The Bernie Mac Show in 2002. The Oscar-winning actor appeared as himself, joining Bernie and Lucy Lawless in the second season for a round of golf.
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Chelsea Handler joined The Bernie Mac Show for one season 3 episode in 2004. The comedian played Doris Flynt, a teacher at Bryana's school.
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Born Cordozar Calvin Broadus, Jr., Snoop Dogg played a character named Calvin in The Bernie Mac Show's fourth season. He stopped by one 2004 episode, appearing as a store clerk who is often told that he looks like Snoop Dogg.
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Two years before she dropped her self-titled debut studio album, JoJo popped up in a season 2 episode of The Bernie Mac Show. The singer played Vanessa's friend Michelle Cooper in a 2002 installment.
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Serena Williams hit the small screen in 2006, playing herself in The Bernie Mac Show's fifth season. The tennis player popped up in one Bernie's confessionals, weighing in on relationships between sisters.
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Billy Crystal was one of the first guest stars on The Bernie Mac Show, appearing in one episode in the first season. The actor played himself in the 2002 installment, also joining Bernie for one of his confessionals.
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Don Cheadle signed on for one 2002 episode of The Bernie Mac Show. The actor played Cousin D at the end of the first season, a relative of Bernie's.
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Bernie found another guest for his confessionals in Ashton Kutcher. The actor played himself in the show's third season, making an appearance to consult on the family's prank war.
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Taylor Lautner landed one of his first gigs thanks to The Bernie Mac Show. The future Twilight star played a character named Aaron in the show's second season in 2003, appearing as one of Jordan's classmates.
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Ice Cube stopped by The Bernie Mac Show's second season in 2002. The performer played himself, catching up with Bernie during one of his confessionals to talk about parenting.
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Chris Rock also had a confessional chat with Bernie. The comedian made an appearance in The Bernie Mac Show's second season in 2003, the same year the two teamed up for Head of State.
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The year after she kicked off Ellen: The Ellen DeGeneres Show, Ellen DeGeneres joined Bernie for one episode of The Bernie Mac Show. She appeared as herself in the third season in 2004, chatting with the star during one of his confessionals.