More from EW
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Ross Geller and Rachel Green, 'Friends'
Ross Geller (David Schwimmer) and Rachel Green (Jennifer Aniston) spent much of Friends' 10 seasons testing the limits of their relationship. The two broke up and got back together multiple times, with perhaps their most famous split taking place in the fourth season. The two reconcile only to part ways again after a dispute about whether they were on a break or not when Ross slept with another woman.
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Carrie Bradshaw and Jack Berger, Sex and the City
Carrie meets fellow writer Jack in Sex and the City's fifth season, beginning to date him in the sixth season after he's split from his girlfriend. The two have a rocky relationship that finally ends when Berger breaks up with Carrie in the harshest possible way: By leaving her a Post-it note reading, "I'm sorry. I can't. Don't hate me."
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Cory Matthews and Topanga Lawrence, Boy Meets World
One of TV's greatest love stories hit the airwaves in the form of Boy Meets World's Cory and Topanga. The childhood sweethearts temporarily parted ways in a particularly heart-wrenching 1997 episode, when Topanga says goodbye to Cory as her family moves out of town. Despite multiple breakups, the two end up together.
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Sheldon Cooper and Amy Farrah Fowler, The Big Bang Theory
The Big Bang Theory's Amy (Mayim Bialik) and Sheldon (Jim Parsons) made headlines in 2015 with their breakup. The two ended the show's eighth season with a split, cementing the end of their relationship in the first episode of the ninth. There could be hope for a reconciliation, however, as Bialik told EW.com in September 2015 that Amy simply "needs space."
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Ben Wyatt and Leslie Knope, Parks and Recreation
Leslie (Amy Poehler) is forced to end her relationship with Ben (Adam Scott) during the fourth season of Parks and Recreation. Pawnee's finest breaks things off when she realizes that her ties to Ben could jeopardize her political future, but thankfully for Knope fans everywhere, she gets back together with her love soon after.
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Buffy Summers and Angel, Buffy the Vampire Slayer
Buffy (Sarah Michelle Gellar) and Angel (David Boreanaz) famously parted ways in the third season of Buffy the Vampire Slayer. Angel broke things off in the 1999 episode "The Prom," finally deciding that it was no longer smart for the two of them to be together.
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Callie Torres and Arizona Robbins, Grey's Anatomy
Callie (Sara Ramirez) and Arizona (Jessica Capshaw) went through one of the hardest splits on a show full of painful moments. The once-happy couple began to see their relationship dissolve in the ninth season of Grey's, with the amputation of Arizona's leg. After infidelity, counseling, and fights, the two broke up in season 11.
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Dylan McKay and Brenda Walsh, Beverly Hills, 90210
Brenda (Shannen Doherty) got her heart broken in the third season of 90210, when Dylan (Luke Perry) chose Kelly (Jennie Garth) over her. The relationship between the former high school sweethearts falls apart after a pregnancy scare, family drama, infidelity, and pressures about the future.
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Lorelai Gilmore and Luke Danes, Gilmore Girls
Much to the despair of Gilmore Girls fans, Luke (Scott Patterson) and Lorelai (Lauren Graham) called off their wedding plans in the show's sixth season. Lorelai finds comfort in Rory's dad Christopher, and does not fully reconcile with Luke until the end of the show's run.
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Ryan Atwood and Marissa Cooper, The O.C.
The rocky relationship of Ryan (Benjamin McKenzie) and Marissa (Mischa Barton) went through one terrible over-the-phone breakup during The O.C.'s third season. Marissa sits on the beach as Ryan breaks things off, ending it as the two come to the conclusion that things aren't working.
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Ted Mosby and Robin Scherbatsky, How I Met Your Mother
The tortured relationship of Ted (Josh Radnor) and Robin (Cobie Smulders) comes to a close in the second season of HIMYM. While there are reconciliations and unrequited feelings in the future, the two call things off ahead of Lily and Marshall's wedding. But it's not until the series finale that we finally get closure on this relationship.
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Zack Morris and Kelly Kapowski, Saved by the Bell
While Zack (Mark-Paul Gosselaar) and Kelly (Tiffani Thiessen) end up together in the end, they go through a breakup in the second season of Saved by the Bell. The high school lovebirds eventually find their way back to one another, tying the knot in Saved by the Bell: Wedding in Las Vegas.