1 of 13
Mal in Inception
One of two female characters in the spectacular summer hit, Cotillard's Mal may be the deceased wife of Leonardo DiCaprio's dream stealing Dom, but her haunting beauty, combined with the troubling nature of most of her appearances, more than brings the character to life.
2 of 13
Alice in Resident Evil: Afterlife
She's baaaaack and hotter than ever. Jovovich's zombie-killing Alice returns this fall for the third installment of the franchise, this time in 3-D. A butt-kicking beauty in 3-D on the big screen...what's not to love?
3 of 13
Olivia Dunham on Fringe
Even in a plain black suit, the long-legged FBI agent has a bad-ass strut we can't take our eyes off of. And thanks to the emergence of Fauxlivia, we get to see Torv as both a blond and a (sort of) redhead.
More with Anna Torv at Comic-Con 2010:
Anna Torv on EW's Women Who Kick Ass panel at Comic-Con 2010
4 of 13
Quorra in Tron: Legacy
Wilde takes on an amazing digital landscape in this sequel to the 1982 cult classic. We're guessing no drab doctor's clothes for her here, and for that we are grateful.
5 of 13
Tamina in Prince of Persia: The Sands of Time
In her first action role, Arterton not only held her own as the protector of the Dagger of Time, but she also fit right in with the film's beautifully rich Morroccan sets, proving her own timeless beauty.
6 of 13
Zoe Graystone in Caprica
After Zoe's death, the troubled girl may have become the first Cylon robot but the sultry Torresani's portrayal brings a definite flesh-and-blood quality to the role.
7 of 13
Leila in The Event
Okay, no one knows what the event is...but what's not in question is how much we're looking forward to this conspiracy thriller show — and watching the gorgeous former model lead us through it all.
8 of 13
Lois Lane on Smallville
It's a bird, it's a plane, it's the sexiest, sassiest, shrewdest Lois Lane since Margot Kidder. And now that Lois knows Clark's secret and will appear in 22 episodes the final season of Smallville, the radiant leading lady is poised to shine even brighter.
More with Erica Durance at Comic-Con 2010:
Erica Durance talks Smallville with Michael Ausiello in San Diego
9 of 13
Kate Austen on Lost
Throughout most of Lost's six seasons, Kate and her sexy, tomboy swagger mesmerized both Jack and Sawyer. And even though Jack proved to be her one and only at the end of it all, she never stopped being the girl every guy wanted.
10 of 13
Sun Hwa Kwon on Lost
We've loved watching our perception of the breathtakingly beautiful Sun go from that of a scared, submissive wife to an adulterous, fiercely loyal survivor. And of course, we mourned her death in the final season. But as anyone who's ever Google Image searched Kim knows, her Sun character's subdued style didn't even begin to capture this woman's hotness. How do you say ''cold shower'' in Korean?
11 of 13
Allison Blake on Eureka
Some sci-fi geeks will remember Richardson-Whitfield from guest stints on Star Trek: Deep Space Nine, Stargate SG-1, and Gargoyles, but she's really come into her own as the sultry, stern, all-business Allison, director of Global Dynamics — the mega-company that employs many of the geniuses that live in the town of Eureka. (She was also woman enough to land Will Smith as a husband — in 2007's I Am Legend, anyway.)
12 of 13
Echo on Dollhouse
Fox's Dollhouse may have aired its final episode earlier this year but from the highly-anticipated start (including a nude promo shoot for the first season) to the much-lauded end, Dushku and her numerous costumes never failed to capture our attention.
13 of 13