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'X-Men: Apocalypse' trailer: Forget everything you think you know

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Backed by a dramatic cover of Coldplay’s “Don’t Panic” (from singer Charity), the new trailer for Bryan Singer’s X-Men: Apocalypse has arrived with four horsemen in tow.

Focused on the world-destroying villain, the globe’s first mutant, Apocalypse teases the end of humanity and maybe even an X-Men member or two.

“Forget everything you think you know,” Jennifer Lawrence’s Mystique tells the young students of Charles Xavier’s School for Gifted Youngsters. “You’re not students anymore; you’re X-Men.” Moments later, Apocalypse (Oscar Isaac) is choking the life out of her.

RELATED: Check out EW’s Exclusive Photos of X-Men: Apocalypse

Starring Lawrence, Isaac, James McAvoy, Michael Fassbender, Nicholas Hoult, Rose Byrne, Tye Sheridan, Sophie Turner, Olivia Munn, Lucas Till, Evan Peters, Kodi Smit-McPhee, Alexandra Shipp, Josh Helman, Lana Condor, and Ben Hardy, X-Men: Apocalypse is out in theaters on May 27. Check out the new trailer above.