Monty Brinton/CBS
Sandra Gonzalez
October 23, 2013 AT 12:00 PM EDT

The stares exchanged between Bob Newhart and Bill Nye the Science Guy in the exclusive photo above from the upcoming Nov. 7 episode of The Big Bang Theory are powerful enough to set off some sort of chemical reaction, which makes us even more excited for this clash of the science titans.

Per the episode description, Professor Proton (Newhart) reaches out to Leonard (Johnny Galecki) seeking help for an experiment. When Sheldon (Jim Parsons), a fan of Proton’s, finds out, he retaliates by befriending Proton’s TV host rival, Nye.

Nye, as you may recall, is just coming off a short run on Dancing With the Stars, while Newhart recently took home an Emmy for his first appearance on the hit CBS comedy. 

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