Adam B. Vary
September 24, 2012 AT 12:00 PM EDT

Spend five minutes talking to The Big Bang Theory‘s Jim Parsons, Simon Helberg, Kaley Cuoco, Kunal Nayyar, and Johnny Galecki, and two things become clear: One, these castmates express their genuine warmth and affection for each other by a near-constant stream of good-natured teasing. And two, trying to steer their conversation is like attempting to corral Sheldon after he’s had coffee — it’s best just to enjoy the ride.

Case in point: When EW sat down with the Big Bang quintet after their photo shoot for this week’s cover story on the CBS hit, we asked each actor to share their personal favorite moment in the entire series for their respective characters. Things did not quite go as planned. Check out their answers, which stretched across all five seasons of the show, below:

The Big Bang Theory‘s sixth season premieres at 8 p.m. ET on Thurs., Sept. 27.

Follow @adambvary

Read more:

This week’s cover: Inside the phenomenon that’s ‘The Big Bang Theory’

‘The Big Bang Theory’: Howard and Bernadette argue…in spaaaaace! — EXCLUSIVE VIDEO

‘The Big Bang Theory’: Greatest Geeky Guest Stars

You May Like