November 10, 2010 at 04:56 PM EST

They’ve got five Oscar nominations and three wins between them. And now Nicole Kidman and Dianne Wiest are firmly in the running for nods this year for their performances as mother and daughter in John Cameron Mitchell’s adaptation of David Lindsay-Abaire’s Pulitzer Prize-winning play Rabbit Hole (out Dec. 17). Although they both play women who have lost children, the two of them actually provide some of the intense film’s lighter moments. In this clip provided by Lionsgate, Wiest’s character, Nat, tells Kidman’s Becca about a friend who got on her nerves after her son died of a drug overdose. This scene had the crowd howling at the Rabbit Hole premiere in Toronto.

Check back here in the coming weeks for more exclusive clips from this season’s top Oscar contenders.

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